Sex Differences in the Contextual Control of Conditioned Pain Tolerance
Pain Research Forum, 5 August 2022
The exact process underlying the transition from acute to chronic pain is unknown, but the persistence or strengthening of acute pain memories has been hypothesized to contribute to the development of chronic pain.
Now, new research led by first author Sydney Trask (Purdue University, Indiana, US), in collaboration with senior author Kate Sadler (Medical College of Wisconsin, US), provides the first preclinical test of this hypothesis.
By repeatedly pairing a noxious visceral stimulus (acetic acid) with a unique context (a behavioral chamber), Trask and Sadler observed… Read more.